2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W008216
    HMMNI
    		99.91%
    HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazole (HY-B1244). Dimetridazole is a nitroimidazole class drug that combats protozoan infections.
    HMMNI
  • HY-133980A
    O-Demethyl Lenvatinib hydrochloride
    O-Demethyl Lenvatinib hydrochloride is a metabolite of Lenvatinib (HY-10981). Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET. Lenvatinib shows potent antitumor activities.
    O-Demethyl Lenvatinib hydrochloride
  • HY-W017434
    3,4-Dimethylbenzoic acid
    		98.32%
    3,4-Dimethylbenzoic acid acts as a product of dimethylbenzoate metabolism by Rhodococcus rhodochrous N75.
    3,4-Dimethylbenzoic acid
  • HY-135359
    RP 48497
    		99.79%
    RP 48497, an impurity of Eszopiclone, is a photodegradation product of Eszopiclone. Eszopiclone is a non-benzodiazepine agent used in the treatment of insomnia.
    RP 48497
  • HY-126996
    Triiodothyronine sulfate
    		≥98.0%
    Triiodothyronine sulfate is the main metabolite of thyroid hormone triiodothyronine (T3). Triiodothyronine is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity.
    Triiodothyronine sulfate
  • HY-W014225
    3-Phenoxybenzoic acid
    		99.81%
    3-Phenoxybenzoic acid is the metabolite of pyrethroid insecticides. 3-Phenoxybenzoic acid induces immunotoxicity and oxidative stress, and inhibits the phagocytic ability of macrophages.
    3-Phenoxybenzoic acid
  • HY-N6695
    Aflatoxicol
    		99.9%
    Aflatoxin (Aflatoxin R0) is a metabolite of aflatoxin B1 produced from Rhizopus spp, and is mutagenic and carcinogenic mycotoxin.
    Aflatoxicol
  • HY-B1022
    Dimesna
    		≥98.0%
    Dimesna combined with anticancer chemotherapeutic agents to reduce nephrotoxicity.
    Dimesna
  • HY-138627A
    AST5902 trimesylate
    		98.75%
    AST5902 trimesylate is the principal metabolite of Alflutinib (AST2818) both in vitro and in vivo. AST5902 trimesylate exerts antineoplastic activity. Alflutinib is an EGFR inhibitor.
    AST5902 trimesylate
  • HY-131964
    Imidacloprid-urea
    		99.86%
    Imidacloprid-urea is a metabolite of Imidacloprid. Imidacloprid is an effective and widely used neonicotinoid pesticide to control pests of cereals, vegetables, tea and cotton. Imidacloprid-urea can occupy or block adsorption sites of imidacloprid on soil, potentially affecting the fate, transport, and bioavailability of imidacloprid in the environment.
    Imidacloprid-urea
  • HY-33914
    4-Hydroxymethylpyrazole
    		99.74%
    4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole (HY-B0876). Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase.
    4-Hydroxymethylpyrazole
  • HY-15876
    Clopidogrel thiolactone
    		≥98.0%
    Clopidogrel thiolactone is an important intermediate in the metabolism of clopidogrel (HY-15283). Clopidogrel thiolactone has antiplatelet aggregatione effects. Clopidogrel is a P2Y12 receptor inhibitor that exerts antiplatelet effects.
    Clopidogrel thiolactone
  • HY-125643
    Pitavastatin lactone
    		99.30%
    Pitavastatin lactone is a major metabolite of Pitavastatin in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes.
    Pitavastatin lactone
  • HY-W012187
    3,5-Di-tert-butyl-4-hydroxybenzaldehyde
    		99.95%
    3,5-Di-tert-butyl-4-hydroxybenzaldehyde (BHT-CHO) is a metabolite of Butylated hydroxytoluene (HY-Y0172) .
    3,5-Di-tert-butyl-4-hydroxybenzaldehyde
  • HY-137989A
    Voriconazole N-oxide hydrochloride
    		99.52%
    Voriconazole N-oxide (Voriconazole oxynitride) (hydrochloride) is the main metabolite of Voriconazole (HY-76200) , a widely used triazole antibiotic (fungal). Voriconazole N-oxide (hydrochloride) provides information on the patient's drug metabolism capacity.
    Voriconazole N-oxide hydrochloride
  • HY-W004298
    10-Undecen-1-ol
    		99.56%
    10-Undecen-1-ol, converted from ricinoleic acid, can be used as a comonomer for the introduction of functional groups.
    10-Undecen-1-ol
  • HY-B1109
    N-Acetylprocainamide
    		99.89%
    N-Acetylprocainamide is a class III antiarrhythmic, which blocks K+ channels.
    N-Acetylprocainamide
  • HY-G0017S
    N-Desmethyl imatinib-d8
    		99.95%
    N-Desmethyl imatinib-d8 is a deuterium labeled Imatinib metabolite N-Desmethyl Imatinib.
    N-Desmethyl imatinib-d<sub>8</sub>
  • HY-B1348
    Dimethadione
    		99.93%
    Dimethadione is the primary metabolite of trimethadione. Dimethadione causes depression of neuromuscular transmission. Dimethadione primarily decreases transmitter release from the nerve terminal.
    Dimethadione
  • HY-I0177
    Vilazodone carboxylic acid
    		98.20%
    Vilazodone carboxylic acid is a vilazodone metabolite observed in both urine (major) and plasma (minor).
    Vilazodone carboxylic acid
Cat. No. Product Name / Synonyms Application Reactivity