2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-135334
    ACP-5862
    		98.41%
    ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC50 of 5.0 nM for Bruton tyrosine kinase (BTK). ACP‐5862 is a weak time‐dependent inactivator of CYP3A4 and CYP2C8. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC50 of 3 nM and EC50 of 8 nM.
    ACP-5862
  • HY-119124
    Edoxaban M4
    		99.13%
    Edoxaban M4, an active metabolite of Edoxaban, shows reproducible, but concentration-dependent matrix effects. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor .
    Edoxaban M4
  • HY-141776S
    Omeprazole sulfide-d3
    		99.79%
    Omeprazole sulfide-d3 is the deuterium labeled Omeprazole sulfide. Omeprazole metabolite Omeprazole sulfide (Ufiprazole) is a metabolite of Omeprazole, which is a proton pump inhibitor.
    Omeprazole sulfide-d<sub>3</sub>
  • HY-33914
    4-Hydroxymethylpyrazole
    		99.74%
    4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole (HY-B0876). Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase.
    4-Hydroxymethylpyrazole
  • HY-100638A
    RPR132595A hydrochloride
    		99.46%
    RPR132595A (NPC) hydrochloride is an active metabolite of CPT-11, which is generated by cytochrome P-450 3A4 (CYP3A4) and finally excreted through urine.
    RPR132595A hydrochloride
  • HY-142122
    Imipramine N-oxide
    		99.90%
    Imipramine N-oxide is the metabolite of Imipramine. Imipramine is a tertiary amine tricyclic antidepressant.
    Imipramine N-oxide
  • HY-N8210
    Homoeriodictyol
    		99.79%
    Homoeriodictyol is a flavonoid metabolite of Eriocitrin in plasma and urine. Eriocitrin is a strong antioxidant agent.
    Homoeriodictyol
  • HY-148682
    18β-Glycyrrhetyl-3-O-sulfate
    		98.01%
    18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)) is a potent type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) inhibitor with an IC50 of 0.10 µM using rat kidney microsome. 18β-Glycyrrhetyl-3-O-sulfate is the major metabolite of Glycyrrhetinic acid (GA). 18β-Glycyrrhetyl-3-O-sulfate is the substrate of organic anion transporter (OAT) 1 and OAT3. 18β-Glycyrrhetyl-3-O-sulfate has anti-inflammatory effects and has the potential for pseudohyperaldosteronism research.
    18β-Glycyrrhetyl-3-O-sulfate
  • HY-126848
    Diclofenac acyl glucuronide
    Diclofenac acyl glucuronide (D-1-O-G) is a major bile metabolite directly involved in small intestinal ulceration in rats.
    Diclofenac acyl glucuronide
  • HY-W012187
    3,5-Di-tert-butyl-4-hydroxybenzaldehyde
    		99.81%
    3,5-Di-tert-butyl-4-hydroxybenzaldehyde (BHT-CHO) is a metabolite of Butylated hydroxytoluene (HY-Y0172) .
    3,5-Di-tert-butyl-4-hydroxybenzaldehyde
  • HY-137989A
    Voriconazole N-oxide hydrochloride
    		99.52%
    Voriconazole N-oxide (Voriconazole oxynitride) (hydrochloride) is the main metabolite of Voriconazole (HY-76200) , a widely used triazole antibiotic (fungal). Voriconazole N-oxide (hydrochloride) provides information on the patient's drug metabolism capacity.
    Voriconazole N-oxide hydrochloride
  • HY-W004298
    10-Undecen-1-ol
    		99.56%
    10-Undecen-1-ol, converted from ricinoleic acid, can be used as a comonomer for the introduction of functional groups.
    10-Undecen-1-ol
  • HY-W011311
    Eicosapentaenoic acid methyl ester
    		99.11%
    Eicosapentaenoic acid methyl ester is a degradant of a monogalactosyl diacylglycerol (an anticancer compound by inducing apoptosis).
    Eicosapentaenoic acid methyl ester
  • HY-16445B
    CNDAC hydrochloride
    		99.59%
    CNDAC hydrochloride is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC hydrochloride induces DNA damage and apoptosis.
    CNDAC hydrochloride
  • HY-I0177
    Vilazodone carboxylic acid
    		98.20%
    Vilazodone carboxylic acid is a vilazodone metabolite observed in both urine (major) and plasma (minor).
    Vilazodone carboxylic acid
  • HY-W006000
    Tetrachlorocatechol
    		98.17%
    Tetrachlorocatechol is a metabolite of pentachlorophenol. Tetrachlorocatechol is one of the most toxic chlorinated catechol produced by the chlorobleaching of pulp and frequently found in the kraft pulp mill effluents.
    Tetrachlorocatechol
  • HY-W012982
    3-Amino-2-oxazolidinone
    		≥98.0%
    3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone (HY-B1336). 3-Amino-2-oxazolidinone is always be detected as a indicator of furazolidone residues in vivo.
    3-Amino-2-oxazolidinone
  • HY-131466
    N-Methyl Palbociclib
    		99.94%
    N-Methyl Palbociclib is an impurity of Palbociclib (HY-50767). Palbociclib (PD 0332991) is an orally active selective CDK4 and CDK6 inhibitor.
    N-Methyl Palbociclib
  • HY-B1984
    p,p'-DDD
    		99.71%
    p,p'-DDD is a major metabolite of p,p'-DDT. p,p'-DDD occurs in the feces and livers of rats, that are given p,p'-DDT by stomach tube, but not of rats injected intraperitoneally with p,p'-DDT.
    p,p'-DDD
  • HY-135356
    m-Nifedipine
    		99.68%
    m-Nifedipine is an impurity of Nifedipine (BAY-a-1040). Nifedipine is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.
    m-Nifedipine
Cat. No. Product Name / Synonyms Application Reactivity